长期睡眠不足人群中脉搏波传导速度与动脉粥样硬化危险因素的相关性研究

目的:研究长期睡眠不足人群中脉搏波传导速度与动脉粥样硬化危险因素的相关性,探讨肱-踝脉搏波传导速度(baPWV)早期预测长期睡眠不足人群中心脑血管事件发生的意义。方法:选择临床未检出患有心脑血管疾病的长期睡眠不足者(持续3个月每日睡眠时间<7h)120例,以睡眠充足(每日睡眠时间>7h)健康体检者110例为健康对照组。同时分别测定其血脂、血糖和胰岛素抵抗指数(HOMA-IR)、颈动脉内膜中层厚度(IMT)和baPWV,分析睡眠不足者baPWV与动脉粥样硬化危险因素间的相关性。结果:与健康对照组比较,睡眠不足组血压、TG、LDL-C、空腹血糖、IMT、HOMA-IR、baPWV均显著升高,HDL-C水平显著降低(P<0.05或<0.01),且baPWV和BMI、SBP、DBP、TC、TG、LDL-C、空腹血糖、HOMA-IR、颈动脉IMT和睡眠不足病程呈显著正相关(r=0.231~0.784,P<0.05或<0.01),多元逐步回归分析发现SBP、baPWV是影响长期睡眠不足人群颈动脉IMT的独立危险因素(OR=1.117、1.158,P=0.013、0.001)。结论:睡眠不足人群中baPWV与颈动脉内膜中层厚度呈显著正相关,提示baPWV对于预测长期失眠人群发生动脉粥样硬化及心脑血管事件有重要临床意义。

Correlation between pulse wave velocity and risk factors of atherosclerosis in people with long-term lack of sleep

Objective:To study correlation among risk factors of atherosclerosis and pulse wave velocity(PWV)in people with long-term lack of sleep,and explore significance of brachial-ankle PWV(baPWV)in early prediction of cardio-and cerebrovascular events in these people.Methods:A total of 120 subjects without cardio-and cerebrovascular diseases,who were lack of sleep for a long period(daily sleep time<7 hfor continuous three months),were selected as lack-of-sleep group;another 110 healthy subjects with full sleep(daily sleep time>7 h)were regarded as healthy control group.Levels of blood lipids,blood glucose,homeostasis model-insulin resistance index(HOMAIR),carotid intima-media thickness(IMT)and baPWV were measured and compared between two groups,and correlation among risk factors of atherosclerosis and baPWV was analyzed in those people with lack of sleep.Results:Compared with healthy control group,there were significant rise in levels of blood pressure,TG,LDL-C,fasting blood glucose(FBG),IMT,HOMA-IR and baPWV,and significant reduction in HDL-C level in lack-of-sleep group,P<0.05 or<0.01;baPWV was significant positively correlated with BMI,SBP,DBP,TC,TG,LDL-C,FBG,HOMA-IR,carotid IMT and course of lack of sleep(r=0.231~0.784,P<0.05 or<0.01).Multivariate gradual regression analysis indicated that SBP and baPWV were independent risk factors for carotid IMT in people with long-term lack of sleep(OR=1.117,1.158,P=0.013,0.001).Conclusion:In people with lack of sleep,baPWV is significantly positive correlated with carotid IMT,suggesting that baPWV is of important significance in early prediction of atherosclerosis,cardio-and cerebrovascular events in these people.