冠状动脉钙化研究进展

冠状动脉钙化(CAC)是导致一般人群和冠状动脉性心脏病患者不良结局的危险因素。CAC的发病机制和骨形成有共同的途径,目前已经确定了一些导致CAC发生和发展的危险因素。用药物治疗控制CAC的努力没有取得成功,而冠状动脉钙化的患者经皮冠脉介入术和冠状动脉搭桥术后的无事件生存率也较低。虽然应用药物洗脱支架和斑块修饰装置对钙化血管的预后有一定改善,但不良事件发生率仍然很高。在未来,仍需创新的药物和器械治疗来改善CAC患者的不良预后。

Coronary Artery Calcification

Coronary artery calcification( CAC) is a risk factor for adverse outcomes in the general population and in patients with coronary artery disease. The pathogenesis of CAC shares a common pathway with bone formation,and some risk factors leading to the occurrence and development of CAC have been identified. Efforts to control CAC with medication have not been successful,and patients with coronary artery calcification have lower event-free survival after percutaneous coronary intervention and coronary artery bypass grafting.Although drug-eluting stents and plaque modifying devices have improved the prognosis of calcified vessels,the incidence of adverse events remains high. In the future,innovative drugs and devices are still needed to improve the poor prognosis of patients with CAC.