2型糖尿病和动脉粥样硬化性心血管病的关系

动脉粥样硬化性心血管病是2型糖尿病患者死亡和残疾的主要原因,2型糖尿病患者发生动脉粥样硬化病变的风险显著高于非糖尿病患者。虽然目前关于2型糖尿病与动脉粥样硬化发生和发展之间的关系尚未完全阐明,但大量基础与临床研究已证实二者之间存在密切的内在联系。现有研究提示,2型糖尿病患者发生动脉粥样硬化病变的机制可能涉及高血糖、胰岛素抵抗、血管钙化、氧化应激、内皮功能障碍和炎症反应等。结合近年来最新的研究结果,现总结分析2型糖尿病与动脉粥样硬化性心血管病之间的潜在联系与可能机制。

Relationship Between Type 2 Diabetes Mellitus and Atherosclerotic Cardiovascular Disease

Atherosclerotic cardiovascular disease is the principal cause of death and disability among patients with type 2 diabetes mellitus.Patients with type 2 diabetes mellitus have a significantly higher risk of atherosclerotic lesions than non-diabetic patients.Although the relationship between type 2 diabetes mellitus and the development of atherosclerosis has not been fully clarified,a large number of basic and clinical studies have confirmed the close relationship between type 2 diabetes mellitus and atherosclerosis.Available studies suggest that the mechanism of atherosclerotic lesions in type 2 diabetes mellitus patients may involve hyperglycemia,insulin resistance,vascular calcification,oxidative stress,endothelial dysfunction,inflammatory response,etc.Based on the latest research results in recent years,we will summarize and analyze the potential connection and possible mechanism between type 2 diabetes mellitus and atherosclerotic cardiovascular disease in this article.