终末期肝病合并真菌感染诊治的热点与难点

终末期肝病(end-stage liver disease,ESLD)患者由于住院时间长、免疫功能调节失衡、多合并有细菌感染且常因行侵袭性操作等原因,在临床上合并真菌感染并不少见.由于其表现不典型不易早期发现,ESLD一旦合并真菌感染往往诱发或者加重疾病进展、病死率增加.因此,本文主要就近年来有关ESLD患者合并真菌感染的流行病学、危险因素、临床表现及处理方法等热点及难点问题的研究进展进行阐述,以供临床医生参考.

Hot topics and difficult problems in diagnosis and treatment of endstage liver disease with fungal infection

Patients with end stage liver disease(ESLD) accompanied by fungal infection are clinically common because of long-term hospitalization,imbalance of immune function regulation,common bacterial infections,and invasive operations.Because of its atypical manifestations,it is not easy to detect fungal infection early.Once ESLD is combined with fungal infection,it often induces or aggravates disease progression and increases mortality.This article reviews the progress in the research of epidemiology,risk factors,clinical manifestations,and treatment methods for fungal infection in ESLD patients with an aim to provide reference for clinicians.