肝癌栓塞后坏死和自然坏死的比较研究

作者用光镜单盲观察１２例经肝动脉碘油抗癌药化疗栓塞（Ｌｐ－ＴＡＥ）和１４例未行Ｌｐ－ＴＡＥ治疗而切除的肝癌标本坏死的病理组织学变化。重点比较肝癌栓塞后坏死和自然坏死的不同。结果表明：肝癌栓后的主要病理变化是大片凝固性坏死；按时间变化分三期：即坏死进行期、机化期和瘢痕期。栓后坏死严重、范围广，呈单相性且坏死机化明显；自然坏死则较轻、范围小，呈多相性，坏死机化不明显，这为准确客观判断Ｌｐ－ＴＡＥ疗效提

A comparative study on the necrosis of hepatocellular carcinomacaused by transcatheter arterial chemoembolization and the sponta- neous necrosis

Histopathological changes were studied in the necrosis of hepatocellular carcinoma(HCC )of 12 cases treated with transcatheter hepatic arterial chemoernbolization using lipiodol(Lp-TAE)and in the spon- taneous necrosis of HCC of 14 cases.The results showed that the main pathologic change with Lp-TAE was massive coagulative necrosis.Histological changes in the necrotic area following Lp-TAE were divided into three stages in time :namely progression period,organization period and scarring period.The Lp-TAE necrosis was severe,extensive in area and monotonous with marked organization,whereas the spontaneous necrosis was mild,small in area and multiphasic witn minimal organization. These findings will provide histopathological basis for the accurate assessment of the embolization effect of Lp-TAE.