ATROPHIC GASTRITIS INDUCED BY INJECTION OF XENOGENEIC STOMACH ANTIGEN IN MICE |
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| Authors: | Hiromitsu Watanabe Masashi Naito Akihiro Ito |
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| Affiliation: | Department of Cancer Research, Research Institute for Nuclear Medicine and Biology, Hiroshima University, Hiroshima |
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| Abstract: | Wistar/Furth rat stomach antigen emulsified with an equal volume of Freund's complete adjuvant was subcutaneously injected into several strains of mice. Atrophy of the glandular stomach was produced in A/HeJ mice, but not in CF1, C57BL/6J or ICR/JGL mice. Atrophy of the glandular stomach was found to become most severe in 4-month-old animals. In 6-month-old mice and 12-month-old mice, atrophy was not observed. The increase in atrophy corresponds with the dose of antigen. |
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