Enzymatic synthesis of a dihydrobenzofuran neolignan by oxidative coupling |
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Authors: | Hosup Yeo Jou Heon Lee Jinwoong Kim |
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Affiliation: | College of Pharmacy, Seoul National University, Korea. |
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Abstract: | The oxidative dimerization of ferulic acid has been carried out using horse-radish peroxidase as catalyst to give a dihydrobenzofuran neolignan (1), the structure of which was elucidated as (2SR,3RS)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-n-buto xycarbonyl-5-(2E-carboxyethenyl)-7-methoxybenzofuran by spectroscopic analyses. This compound showed more potent cytotoxicity against several tumor cell lines than the starting material. |
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Keywords: | Oxidative dimerization Peroxidase Ferulic acid Dihydrobenzofuran neolignan Cytotoxicity |
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