Concentrations of thioridazine and thioridazine metabolites in erythrocytes |
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Authors: | Charlotte Svensson Gösta Nyberg Rolf Axelsson Erik M»rtensson |
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Affiliation: | (1) Psychiatric Department III, University of Göteborg, Lillhagen Hospital, 42203 Hisings Backa, Sweden |
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Abstract: | The concentrations of thioridazine and its main metabolites in erythrocytes from 61 thioridazine-treated patients were determined by gas-liquid chromatography. The mean and range of the erythrocyte concentrations, expressed as percentage of the corresponding plasma concentrations, were: thioridazine, 5.1% (2.0–10.6); side-chain sulfoxide, 5.6% (1.6–10.4); side-chain sulfone, 3.3% (1.1–6.8); ring sulfoxide 2.7% (0.8–4.9). The erythrocyte and plasma concentrations were significantly correlated. The erythrocyte/plasma concentration ratios, all the erythrocyte concentrations, but none of the plasma concentrations except ring sulfoxide were significantly positively correlated to the dose of thioridazine. The erythrocyte/plasma concentration ratio was not correlated to age. In vitro experiments indicated no clinically relevant erythrocyte-mediated oxidation of thioridazine.Offprint requests to: E. Märtensson |
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Keywords: | Thioridazine Thioridazine metabolites Erythrocytes Psychiatric patients Analytical method |
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