活动期类风湿关节炎患者血清人类软骨糖蛋白-39水平测定的意义

目的研究活动期类风湿关节炎（RA）患者血清人类软骨糖蛋白-39（HC gp-39）的水平及意义。方法选取47例初诊活动期、42例非活动期RA患者和38名健康查体者,采用酶联免疫吸附试验（ELISA）测定血清HC gp-39水平,同时测定关节肿胀数（SJC）、关节压痛数（TJC）、红细胞沉降率（ESR）、C反应蛋白（CRP）、类风湿因子（RF）等相关实验室指标。结果活动期RA患者血清HC gp-39水平明显高于非活动期RA患者及正常对照者（P〈0.01）。非活动期RA患者与正常对照者HC gp-39水平差异无统计学意义（P〉0.05）。不同X线分期患者HC gp-39水平差异有统计学意义（P〈0.05）,不同关节功能分级时差异无统计学意义（P〉0.05）。HCgp-39水平与SJC、TJC、ESR、CRP、关节X线分期呈正相关性（P〈0.01）,与年龄、病程、晨僵时间、RF、关节功能分级无明显相关性（P〉0.05）。结论 HC gp-39在活动期RA患者血清中呈高水平表达,可作为反映疾病活动和RA患者出现骨侵蚀的有益预测指标。

The significance of the determination of serum level of human cartilage glycoprotein 39 in patients with active rheumatoid arthritis

Objective To investigate the determination of the serum level of human cartilage glycoprotein 39（HC gp-39） and its significance in patients with active rheumatoid arthritis（RA）.Methods The serum HC gp-39 level was determined in 47 patients with active RA,42 patients with inactive RA and 38 healthy controls by enzyme-linked immunosorbent assay（ELISA）.The swollen joint count（SJC）,tender joint count（TJC）,erythrocyte sedimentation rate（ESR）,C reactive protein（CRP） and rheumatoid factor（RF） were determined.Results Serum HC gp-39 level in active RA patients was significantly higher than those in inactive RA patients and healthy controls（P0.01）,but there was no significant difference between inactive RA patients and healthy controls（P0.05）.HC gp-39 levels in different line X stages had statistical difference（P0.05）,but HC gp-39 levels with different stages of joint function had no significant difference（P0.05）.The serum HC gp-39 level was positively correlated with the SJC,TJC,ESR,CRP and line X stages（P0.01）,but it had no obvious correlation with age,disease course,length of morning stiffness,RF and joint function stages（P0.05）.Conclusions Serum HC gp-39 level increases significantly in active RA patients.It can be used as an indicator for disease activity and a valuable predictor of the progression of bone erosion.