| CYP2C19遗传多态性与膀胱癌易感性关系的研究 |
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| 引用本文： | 金百冶,陈枢青,蔡松良.CYP2C19遗传多态性与膀胱癌易感性关系的研究[J].中华泌尿外科杂志,2000,21(11):656-658. |
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| 作者姓名： | 金百冶 陈枢青 蔡松良 |
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| 作者单位： | 浙江大学医学院附属第一医院泌尿外科,杭州 |
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| 基金项目： | 浙江省自然科学基金!资助 (396 473) |
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| 摘 要： | 目的：观察ＣＹＰ２Ｃ１９遗传多态性与膀胱癌易感性之间的关系。方法：根据ＣＹＰ２Ｃ１９两个突变位点和ＡＳＡ原理设计ＰＣＲ引物，对５０例膀胱癌患者和７０例正常对照者进行ＣＹＰ２Ｃ１９基因分析。结果：膀胱癌组ＣＹＰ２Ｃ１９慢代谢者２例，正常对照慢代谢者１１例；两组间比较差别有显著性意义（Ｐ＜０．０５）。结论：ＣＹＰ２Ｃ１９可能参与膀胱癌前致癌物的活化。
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| 关 键 词： | 膀胱癌 易感性 CYP2C19 遗传多态性 |
The relationship between cytochrome P450 2C19 (CYP2C19) genetic polymorphism and bladder cancer susceptibility |
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| JIN Baiye,CHEN Shuqing,CAI Songliang,et al..The relationship between cytochrome P450 2C19 (CYP2C19) genetic polymorphism and bladder cancer susceptibility[J].Chinese Journal of Urology,2000,21(11):656-658. |
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| Authors: | JIN Baiye CHEN Shuqing CAI Songliang |
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| Institution: | JIN Baiye,CHEN Shuqing,CAI Songliang,et al.Department of Urology,the First Affiliated Hospital of Medical School,Zhejiang University,Hangzhou 310003,China |
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| Abstract: | Objective To clarify the relationship between cytochrome P450 2C19(CYP2C19) genetic polymorphism and bladder cancer susceptibility. Methods Four pairs of PCR primers were designed according to CYP2C19 wild type sequence and the mutations in CYP2C19m1 and CYP2C19m2 by the principle of ASA. The method was employed to genotype CYP2C19 of 50 bladder cancer patients and 70 normal controls. Results 2 CYP2C19 poor metabolizers were found in bladder cancer patients whereas 11 CYP2C19 poor metabolizers were found in controls( P <0.05). Conclusions This result suggested that CYP2C19 might involve in the activation of procarcinogen of bladder cancer. |
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| Keywords: | Bladder neoplasms Carcinoma Genes |
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