白血病抑制因子及其受体mRNA在多囊卵巢综合征中的表达和意义

目的：研究白血病抑制因子（LIF）及白血病抑制因子受体（LIFR mRNA）在多囊卵巢综合征（PCOS）卵巢中的表达，探讨其在PCOS发病中的作用。方法：采用原位杂交技术检测UF及LIFR mRNA在PCOS及对照组卵巢的定位表达。结果：LIF及LIFR mRNA表达于卵巢颗粒细胞和间质细胞，PCOS组颗粒细胞LIFmRNA表达阳性指数（4．41±1．72）较对照组（5．63±1．82）明显减弱（P=0．021），两组间受体mRNA表达差异无显著性（P=0．776）。结论：颗粒细胞LIFmRNA表达下调及其受体mRNA表达失常可能与PCOS发病有关。

Expression and significance of LIFmRNA and LIFRmRNA in PCOS

Objective ：To investigate the expression of LIFmRNA and LIFRmRNA in the ovaries of the patients with PCOS, and to explain the pathogenesis of PCOS. Methods：The mRNA expression of LIF and LIFR were measured by ISH. Results：The expression of LIFmRNA and LIFRmRNA were found in both granulosa cells and intersititial cells,the intensity index of LIFmRNA in granulosa cells of the study group （4.41±1.72） was significantly weaker than （5.63±1.82） of the control group（P=0.021 ） while the expression of LIFRmRNA had no variety （P=0.776）.Conclusion： Downregulation of LIFmRNA and disruption of LIFRmRNA may be one of the pathogenesis of PCOS.