| MMP-14与TIMP-2在子宫腺肌病中的表达及临床意义 |
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| 引用本文： | 黄朝芬,蔡晚霞.MMP-14与TIMP-2在子宫腺肌病中的表达及临床意义[J].现代医药卫生,2009,25(6):822-824. |
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| 作者姓名： | 黄朝芬 蔡晚霞 |
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| 作者单位： | 黄朝芬 (绵阳市疾病预防与控制中心,四川,绵阳,621000)； 蔡晚霞 (川北医学院附属第二医院,四川,绵阳,621000)； |
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| 摘 要： | 目的：探讨MMP-14与TIMP-2在子宫腺肌病异位内膜中的表达及发病机制。方法：采用免疫组织化学方法检测65例子宫腺肌病异位内膜和35例正常子宫内膜中MMP-14与TIMP-2的表达。结果：（1）MMP-14在异位内膜的表达均显著高于正常子宫内膜（〈0．05）。（2）TIMP-2在异位内膜的表达低于正常子宫内膜（P〈0．05）。（3）在正常子宫内膜中MMP-14与TIMP-2呈负相关（r=-0.721，P〈0．05）。结论：MMP-14与TIMP-2在子宫腺肌病中的表达变化，可能有促进子宫内膜在子宫肌层内的异位种植和生长。
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| 关 键 词： | MMP-14 TIMP-2 子宫内膜 异位种植 生长 |
Expression and clinical significance of MMP-14 and TIMP-2 in adenomyoma |
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| Institution: | HUANG Chao-fen, CAI Wan-xia (1.Mianyang Center for Disease Control and Prevention ,Mianyang ,Sichuan 621000 , China ; 2.Second Affiliated Hospital, North Sichuan Medical College ,Mianyang, Sichuan 621000. China) |
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| Abstract: | Objective：To detect the expression of MMP-14 and TIMP-2 in eetopic endometrium of adenomyoma and its relation with the pathogenesis of adenomyoma. Methods：Endometrial specimens were obtained from 35 normal uteri and 65 with adenomyoma. MMP-14 and TIMP-2 were detected by immunohistochemical streptavidin-peroxidase staining. Results： （1）Eetopie endometrium expressed higher levels of MMP-14, than eutopic endometrium from normal and EMs patients（P〈0.05）.（2）Eetopic and eutopic endometrium from EMs patients expressed lower levels of TIMP-2 than normal control endometrium. （3）In the normal control endometrinm there was a statistically significant negative correlation between MMP-14 and TIMP-2 expression levels, with correlation coefficients of -0.721 （P〈 0.01）. Conclusion：The expression of MMP-14 and TIMP-2 in ectopic endometria of adenomyoma may cause to change local angiogenesis and enhance the growth and survival of ectopic endometrial implants. |
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| Keywords: | MMP-14 T IMP-2 Endometrium Ectopic implants Growth |
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