Modulatory influences of red nucleus stimulation on the somatosensory responses of cat trigeminal subnucleus oralis neurons |
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| Authors: | K D Davis J O Dostrovsky |
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| Institution: | 1. Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, 12 Queen Square, WC1N 3BG London, United Kingdom;2. Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, 33 Queen Square, WC1N 3BG London, United Kingdom;3. Nuffield Department of Clinical Neuroscience, University of Oxford, John Radcliffe Hospital, OX3 9DU Oxford, United Kingdom;4. University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands;5. Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, WC1N 3BG London, United Kingdom;6. Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, OX3 9DU Oxford, United Kingdom;7. Medical Research Council Brain Network Dynamics Unit at the University of Oxford, OX3 9DU Oxford, United Kingdom;1. Division of Physical Therapy, Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, USA;2. Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, Canada;3. The Laboratory for Investigative Neurophysiology (The LINE), Department of Radiology and Department of Clinical Neurosciences, University Hospital Center and University of Lausanne, Lausanne, Switzerland;4. Brain Behaviour Laboratory & Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada;1. School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China;2. School of Mechanical Engineering, Southeast University, Nanjing, China;3. Laboratory of Neuromotor Physiology, IRCCS Fondazione Santa Lucia, Rome, Italy;4. Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Italy;5. Institute of Intelligent Industrial Technologies and Systems for Advanced Manufacturing (STIIMA), National Research Council of Italy (CNR), Milan, Italy |
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| Abstract: | Little is known of the effect of red nucleus (RN) stimulation on somatosensory neurons despite its known anatomic projections to somatosensory relay nuclei. The effect of RN stimulation on the somatosensory responses of trigeminal subnucleus oralis (Vo) neurons was investigated in chloralose- or barbiturate-anesthetized cats. Arrays of bipolar stimulating electrodes were inserted into the contralateral and ipsilateral RN and the contralateral thalamus. Extracellular single-unit recordings were obtained in Vo with tungsten microelectrodes. Neurons in Vo were excited to just suprathreshold by electrical stimulation within their receptive fields. Red nucleus influences were studied by applying 100-ms, 500-Hz conditioning trains to the contralateral or ipsilateral RN 130 ms prior to the peripheral test stimulus. The effect of RN stimulation was also tested on mechanically evoked responses of Vo cells. The somatosensory responses of most cells (70/73) were inhibited after RN stimulation. Some of these cells (15/70) could be antidromically activated from the contralateral thalamus. Stimulation of the RN resulted in excitation followed by inhibition in nine Vo cells. The results suggest that the RN may modulate transmission of somatosensory information through Vo. |
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