南瓜多糖降血脂抗动脉粥样硬化的实验研究

目的:探讨南瓜多糖降血脂预防动脉粥样硬化形成的作用机制。方法:将48只大鼠随机分为正常对照组、高脂模型组、南瓜多糖低、高剂量组。实验至第8周末,麻醉后眼球采血,检测血清甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)和丙二醛(MDA)、超氧化物歧化酶(SOD)活性。同时取主动脉作病理形态学观察。结果:与高脂模型组比较,南瓜多糖组大鼠血清TG、TC、MDA含量明显降低,HDL、SOD含量明显提高(P<0.05)。高、低剂量组大鼠主动脉壁厚度和泡沫细胞数量明显较高脂模型组减轻。结论:南瓜多糖具有减缓大鼠动脉粥样硬化形成的作用,其作用可能与降低TG、TC、提高HDL水平、及抗脂质过氧化作用有关.

Study of pumpkin polysaccharide on hyperlipoidemia and anti- atherosclerosis

Objective:To observe the influence of Pumpkin Polysaccharide(PP) on the blood lipid level in experimental hyperlipidemic rats.Methods:Rats were randomly divided into 4 groups :A normal control one,a hyperlipidemia model one,a low dosage one of PP and a high-doasge ome of PP.At the end of the 8th week after rat experiments,we carried out a detection of plasma total cholesterol(TC),tryglyceride(TG),low density lipoprotein(LDL),high density lipoprotein(HDL),superoxidedismutase(SOD) and malonyldialdehyde(MDA).Results:Compared with those in the hyperlipidemia model group,the levels of MDA and TC,TG in the serum of rats givenPP were lower.while the activity of SOD and HDL in the serum of rats given PP were increased.The thickness of aortic valves in rats fed with PP was thinner than which in model rats.Conclusion:The PP has an effect of slowing down atherogensis,the possible mechanism may be related to the decrease of TG,TC,MDA and the increase of HDL SOD and anti-peroxidation