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| 内蒙古包头地区汉族人血管紧张素转换酶基因与糖尿病肾病的相关性研究 | |
| 引用本文： | 谢基明,王玉珍,岳秀兰,秦文斌,雎天林.内蒙古包头地区汉族人血管紧张素转换酶基因与糖尿病肾病的相关性研究[J].内蒙古医学院学报,2006,28(1):14-18. |
| 作者姓名： | 谢基明 王玉珍 岳秀兰 秦文斌 雎天林 |
| 作者单位： | 1. 内蒙古自治区医院,检验科,内蒙古,呼和浩特,010017 2. 浙江大学,免疫研究所 3. 包头医学院 |
| 摘 要： | 目的：探讨血管紧张素转换酶（ACE）基因与糖尿病肾病（DN）发病的关系。方法：用PCR方法检测100例NIDDM病人及63例正常对照的ACE基因型。结果：ACE基因型及等位基因构成比在正常时照组和NIDDM组间无统计学差异；DD基因型及D等位基因频率在DN组（0．06）与非DN组（0.02）之间无显著性差异。结论：ACE基因多态性与DN发病无关。 |
| 关 键 词： | 血管紧张素转换酶基因 糖尿病肾病 |
| 文章编号： | 1004-2113（2006）01-0014-05 |
| 收稿时间： | 2005-03-01 |
| 修稿时间： | 2005-12-23 |
RELATIONSHIP BETWEEN ANGIOTENSIN Ⅰ CONVERTING ENZYME GENE I/D POLYMORPHISM AND DIABETIC NEPHROPATHY IN NIDDM AMONG THE HANS OF BAOTOU, INNER MONGOLIA |
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| XIE Ji-ming, WANG Yu-zhen, YUE Xiu-lan.RELATIONSHIP BETWEEN ANGIOTENSIN Ⅰ CONVERTING ENZYME GENE I/D POLYMORPHISM AND DIABETIC NEPHROPATHY IN NIDDM AMONG THE HANS OF BAOTOU, INNER MONGOLIA[J].Acta Academiae Medicinae Neimongol,2006,28(1):14-18. | |
| Authors: | XIE Ji-ming WANG Yu-zhen YUE Xiu-lan |
| Institution: | Clinical Laboratory, Inner Mongolia Hospital, Hohhot 010017, China |
| Abstract: | Objective: To clarify if ACE gene I/D polymorphism attributes to the development of diabetic nephropathy in NIDDM.Methods: WTBZ]ACE genotypes were detected with PCR amplification among 100 patients with NIDDM and 63 controls who were hans from BaoTou,Inner Mongolia.Results: WTBZ]The genotype distribution was not significantly different between 100 patients with NIDDM and 63 normal controls;The DD genotype frequency was not significently different between DN group(0.06) and normal albuminuria(0.02)($P$>(0.05).) Conclusion: There was no association between ACE gene I/D polymorphism and diabetic nephropathy. |
| Keywords: | angiotensin converting enzyme gene diabetic nephropathy |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |