| AK细胞及环磷酰胺治疗肝癌的实验研究 |
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| 引用本文： | 孙倍成,刘根寿,王学浩,刘庆宏.AK细胞及环磷酰胺治疗肝癌的实验研究[J].实用癌症杂志,1999(4). |
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| 作者姓名： | 孙倍成 刘根寿 王学浩 刘庆宏 |
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| 作者单位： | 南京医科大学第一附属医院!南京市210029(孙倍成，王学浩)，苏州医学院附二院(刘根寿)，扬州大学医学院附属医院(刘庆宏) |
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| 摘 要： | 为研究１ 种新的过继免疫化疗治疗肝癌的方法，采用肝癌细胞株Ｈ２２ 接种于近交系Ｂａｌｂ／ｃ 小鼠皮下，制成肿瘤模型。使用ＩＬ２ 、肿瘤活化的杀伤细胞（ＡＫ细胞）及环磷酰胺（Ｃｙ） 进行治疗，检测小鼠脾淋巴细胞ＮＫ、ＬＡＫ及ＣＴＬ 活性，用流式细胞仪检测Ｌ３Ｔ４ 亚群及Ｌｙｔ２ 亚群含量。结果表明在过继免疫化疗组小鼠ＬＡＫ 及ＣＴＬ活性明显高于其它治疗组（Ｐ＜ ０．０１），荷瘤小鼠肿瘤结节生长较ＩＬ２ 组及Ｃｙ 组明显缓慢（Ｐ＜ ０．０１），生存期也明显高于其它各治疗组（Ｐ＜０ ．０１）。该研究表明过继免疫化疗有较强的抗肿瘤作用。
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| 关 键 词： | AK细胞 环磷酰胺 肝细胞癌 免疫化疗 |
Experimental Study on the Treatment of Hepatocellular Carcinoma by Activated Killer Cells and Cyclophosphamide |
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| Sun Beicheng,Liu Genshou,Wang Xuehao,et al.Experimental Study on the Treatment of Hepatocellular Carcinoma by Activated Killer Cells and Cyclophosphamide[J].The Practical Journal of Cancer,1999(4). |
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| Authors: | Sun Beicheng Liu Genshou Wang Xuehao |
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| Abstract: | This study was to research into a new adoptive immunochemotherapy against hepatocellular carcinoma.Syngeneic Balb/C mice were subcutaneously(S.C) injected with murine hepatocellular carcinoma H22 cells for tumor bearing mice model.Then,interleukin 2(IL 2),cyclophosphamide and activated killer cells(AK) were administered.The activity of natural killer cells(NK),LAK and CTL were detected,L 3T 4 and lyt 2 subsets were measured by FCM.The results showed that the activity of LAK and CTL in the group of immunochemotherapy was significantly higher than in the other groups( P <0.01).After treatment,subcutaneous tumor showed significant growth inhibition( P <0.01),survival time was significant extended( P <0.01).This study implied that immunochemotherapy have powerful antitumor effect. |
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| Keywords: | Activated killer cell Cyclophosphmide Hepatocellular carcinoma Immunochemotherapy |
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