Metabolic and hemodynamic effects of magnesium supplementation in patients with essential hypertension |
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| Authors: | P C Zemel M B Zemel M Urberg F L Douglas R Geiser J R Sowers |
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| Affiliation: | Division of Endocrinology, Nutrition and Hypertension, Wayne State University, School of Medicine, Detroit, MI. |
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| Abstract: | The effect of magnesium supplementation on blood pressure, erythrocyte cation metabolism, and serum lipids was evaluated in 13 patients with mild hypertension. After randomization and a 3-wk placebo run-in period, seven patients received 40 mmol Mg aspartate (20 mmol elemental Mg twice daily) and six received placebo for 3 mo. In comparison with placebo treatment, magnesium aspartate therapy had no effect on blood pressure, lipid concentrations, or erythrocyte cation metabolism. These results demonstrate that in magnesium-repleted hypertensive subjects, magnesium supplementation does not affect blood pressure or lipids probably because magnesium has no effect on cellular cation metabolism in magnesium-replete individuals. |
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