| 紫草油的质量标准改进研究 |
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| 引用本文： | 马秉智,周宇,李英男,赵铁,赫军,陆进,吴彬,杨丽.紫草油的质量标准改进研究[J].中国医院药学杂志,2015,35(3):247-249. |
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| 作者姓名： | 马秉智 周宇 李英男 赵铁 赫军 陆进 吴彬 杨丽 |
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| 作者单位： | 1. 中日友好医院药学部, 北京 100029;
2. 清华大学医院, 北京 100084;
3. 北京市食品药品监督管理局, 北京 100053 |
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| 基金项目： | 首都卫生发展科研专项项目(No.首发2011-2008-01);北京市医疗机构制剂标准评价体系及标准提高研究(NoZ121100000312005) |
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| 摘 要： | 目的:提升紫草油的质量标准。方法:采用薄层色谱(TLC)法对紫草进行定性鉴别;采用高效液相色谱法对β,β'-二甲基丙烯酰阿卡宁(以下简称阿卡宁)进行含量测定。结果:TLC斑点清晰,分离度好,阴性对照无干扰;阿卡宁的检测浓度在12.225~195.600 μg·ml-1范围内与峰面积积分值呈良好线性关系(r=0.999 7),平均回收率为99.80%(RSD=1.05%,n=6)。结论:提升后的标准可以用于紫草油的质量控制。
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| 关 键 词： | 紫草油 紫草 左旋紫草素 阿卡宁 薄层色谱法 高效液相色谱法 |
| 收稿时间： | 2014-04-29 |
Study on improvement of quality standard of Zicao oil |
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| MA Bing-zhi;ZHOU Yu;LI Ying-nan;ZHAO Tie;HE Jun;LU Jin;WU Bin;YANG Li.Study on improvement of quality standard of Zicao oil[J].Chinese Journal of Hospital Pharmacy,2015,35(3):247-249. |
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| Authors: | MA Bing-zhi;ZHOU Yu;LI Ying-nan;ZHAO Tie;HE Jun;LU Jin;WU Bin;YANG Li |
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| Institution: | 1. Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China;
2. Hospital of Tsinghua University, Beijing 100084, China;
3. Beijing Food and Drug Administration, Beijing 100053, China |
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| Abstract: | OBJECTIVE To improve the quality standard for Zicao oil. METHODS TLC was used for identification of Arnebiae Radix. HPLC was applied for the content determination of β,β'-dimethylacrylalkannin. RESULTS TLC spots were clear and well-separated without interference from negative control. The linear range of β,β'-dimethylacrylalkannin was 12.225~195.600μg·ml-1 (r=0.9997,n=5) and its average recovery rate was 99.80% (RSD=1.05%,n=6).CONCLUSION The improved standard can be used for quality control of Zicao oil. |
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| Keywords: | Zicao oil Arnebiae Radix L-shikonin β β'-dimethylacrylalkannin TLC HPLC |
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