| 湖南籍汉族强直性脊柱炎患者IL-1RN基因多态性分析 |
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| 引用本文： | 林琳,陈文贵,扈凤平. 湖南籍汉族强直性脊柱炎患者IL-1RN基因多态性分析[J]. 湖南师范大学学报(医学版), 2006, 3(1): 39-41 |
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| 作者姓名： | 林琳 陈文贵 扈凤平 |
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| 作者单位： | 1. 中南大学基础医学院免疫教研室,湖南,长沙,410013
2. 中南大学医学技术与情报学院检验系,湖南,长沙,400013 |
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| 摘 要： | 目的:研究白介素-1受体拮抗因子(IL-1RN)基因多态性与强直性脊柱炎(ankylosing spondylitis,AS)的相关性。方法:自150名AS患者及92名健康对照者外周血中提取DNA,采用PCR方法检测IL-1RN基因第二内含子VNTR复等位基因多态性。结果:AS患者中IL-1RN*2等位基因频率显著高于健康对照者。结论:AS与IL-1RN*2等位基因相关联。
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| 关 键 词： | 强直性脊柱炎 基因多态性 白介素-1受体拮抗因子 |
| 文章编号： | 1673-016x(2006)01-0039-03 |
| 修稿时间： | 2005-11-11 |
Interleukin-1 Receptor Antagonist Gene Polymorphisims in Hunan Han Ankylosing Spondylitis |
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| LIN Lin,CHEN Wen-gui,HU Feng-ping. Interleukin-1 Receptor Antagonist Gene Polymorphisims in Hunan Han Ankylosing Spondylitis[J]. Journal of Hunan Normal University(Medical Science), 2006, 3(1): 39-41 |
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| Authors: | LIN Lin CHEN Wen-gui HU Feng-ping |
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| Abstract: | Objective To evaluate the relationship of the polymorphism of interleukin-1 receptor antagonist(IL-1RN) gene and patients with ankylosing spondylitis(AS).Methods DNA samples were collected from one hundred and fifty patients with AS and ninety two healthy controls.IL-1RN VNTR polymorphisms were determined by using PCR.Results There was a significantly increased IL-1RN VNTR*2 allelic frequency in patients with AS compared with controls(8.33% vs 3.26%,OR=2.697,P=0.027) Conclusion The polymorphism of IL-1RN gene is strongly associated with the development of AS. |
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| Keywords: | Ankylosing spondylitis Polymorphism IL-1RN |
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