Stereotactic body radiotherapy for isolated paraaortic lymph node recurrence from colorectal cancer |
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Authors: | Mi-Sook Kim Chul Koo Cho Kwang Mo Yang Dong Han Lee Sun Mi Moon Young Joo Shin |
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Affiliation: | Mi-Sook Kim, Chul Koo Cho, Kwang Mo Yang, Dong Han Lee, Sun Mi Moon, Young Joo Shin, Department of Radiation Oncology and Surgery, Korea Institute of Radiological & Medical Sciences, 215-4 Gongneung-dong, Nowon-gu, Seoul 139-706, South Korea |
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Abstract: | AIM: To evaluate the efficacy and complications of stereotactic body radiotherapy in localized paraaortic lymph node recurrence from colorectal cancer. METHODS: From 2003 to 2009, 7 patients with paraaortic lymph node recurrence (1-3 lesions) from colorectal cancer were treated with stereotactic body radiotherapy. Total gross tumor volumes ranged from 4 to 40 mL. The doses were escalated from 36 Gy/patient to 51 Gy/patient and were delivered in 3 fractions. RESULTS: One and 3 year overall survival rates were 100% and 71.4%, respectively, and median survival was 37 mo. Grade Ⅳ intestinal obstruction was reported in 1 of 7 patients. This patient received 48 Gy in 3 fractions with a maximum point dose to the intestine of 53 Gy and V_(45Gy) = 3.6 mL. However, 6 patients received an intestinal maximum point dose of < 51 Gy and V_(45Gy) of < 1 mL, and did not develop any severe complications. CONCLUSION: This pilot study suggests selected paraaortic lymph node recurrence (1-3 closed lesions) that failed to respond to chemotherapy can be potentially salvaged by stereotactic body radiotherapy. |
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Keywords: | Stereotactic body radiotherapy Paraaortic lymph node recurrence Colorectal cancer |
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