Reactivity of monoclonal antibodies 17.13 and 63.12 with oral epithelial dysplasia and hyperkeratosis |
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| Affiliation: | 1. Department of Diagnostic Sciences, School of Dentistry, University of the Pacific. San Francisco, USA;2. Department of Diagnostic Sciences, School of Dentistry, University of the Pacific. San Francisco, USA;3. Division of Oral Medicine, School of Dentistry, University of California, San Francisco. USA;4. Department of Diagnostic Sciences, University of the Pacific. San Francisco, USA;5. Division of Oral Medicine, Department of Stomatology, School of Dentistry, University of California, San Francisco. USA;1. Faculty of Engineering, China University of Geosciences (Wuhan), Wuhan, Hubei, 430074, PR China;2. Beijing Key Laboratory of Metro Fire and Passenger Transportation Safety, China Academy of Safety Science and Technology, Beijing, 100012, PR China;3. State Key Laboratory of Fire Science, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui, 230026, PR China;1. Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA;2. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA;3. Department of Otorhinolaryngology - Head and Neck Surgery, Rabin Medical Center, Petah Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;1. School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou, 510006, PR China;2. Guangzhou Research & Creativity Biotechnology Co. Ltd., Guangzhou, 510663, PR China;1. Education University of Hong Kong, Tai Po, Hong Kong;2. Chinese University of Hong Kong, Shatin, Hong Kong;1. Department of Biomedical Science for Health, Division of General Surgery, University of Milan, Istituto Clinico Sant''Ambrogio, Milan, Italy;2. Department of Surgery, University of Insubria, Istituto Clinico Sant''Ambrogio, Milan, Italy;3. Department of Pathophysiology and Transplantation, INCO and Department of General Surgery, University of Milan, Istituto Clinico Sant''Ambrogio, Milan, Italy |
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| Abstract: | Monoclonal antibodies (MAbs) 17.13 and 63.12 exhibit characteristic reactivity patterns in normal stratified squamous epithelium, as well as highly sensitive and specific altered reactivity patterns in squamous cell carcinoma. The purpose of this study was to critically evaluate the patterns of reactivity of MABs 17.13 and 63.12 in 43 biopsies of clinical oral leukoplakia or erythroleukoplakia with microscopic diagnoses of hyperkeratosis or epithelial dysplasia. Altered carcinoma-like reactivity patterns were seen in 72% of hyperkeratoses and in all cases of epithelial dysplasia, but varied in the level of epithelial strata exhibiting altered reactivity. Increased frequency of altered reactivity within the epithelial strata was associated with the presence, but not the grade of, epithelial dysplasia, as well as with the presence, intensity, and pattern of submucosal inflammation. The results of this study suggest that altered reactivity patterns of MAb 17.13 are associated with epithelial dysplasia and may be of assistance in detecting precancerous changes in hyperkeratoses before morphologically identifiable epithelial dysplasia. The association of submucosal inflammation with altered MAbs 17.13 and 63.12 reactivity may indicate either a decrease in specificity of these antibodies for precancerous change or an increased significance of inflammation in precancerous lesions. |
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