慢性脑供血不足与颈动脉粥样硬化关系的研究

目的研究慢性脑供血不足（CCCI）患者脑血流动力学变化及其颈动脉粥样硬化特点。方法分别对50例CCCI患者（CCCI组）和50例正常对照者（正常对照组）及50例脑梗死患者（脑梗死对照组）行颈动脉彩色多普勒及经颅多普勒检查,并测量相关指标。结果 CCCI组颈动脉粥样斑块发生率为52.0%（26/50）,颈动脉内膜中层厚度〉1.00 mm者占24.0%（12/50）,颈动脉狭窄率为22.0%（11/50）,颅内血流异常率为60.0%（24/40）,颅内血管狭窄率为20.0%（8/40）,而正常对照组分别为14.0%（7/50）,4.0%（2/50）,4.0%（2/50）,16.7%（5/30）,3.3%（1/30）;脑梗死对照组分别为82.0%（41/50）,68.0%（34/50）,48.0%（24/50）,92.6%（25/27）,51.9%（14/27）,CCCI组与正常对照组比较差异有统计学意义（P〈0.01）,脑梗死对照组与CCCI组比较差异亦有统计学意义（P〈0.01）。CCCI组颈动脉彩色超声检查的斑块、不稳定斑块I、MT增厚和颈动脉狭窄发生率及TCD检查的血流速度异常率、RI、PI等介于正常对照组与脑梗死对照组之间。结论 CCCI是动脉粥样硬化过程的一个阶段,是脑梗死的预兆。CCCI是血栓前状态,是脑梗死的后备军,斑块的不稳定性是急性脑梗死重要危险因素。

Relationship of chronic cerebral circulation insufficiency and carotid artery atherosclerosis

Objective To study the characters of cerebral blood flow and atherosclerosis in the patients with chronic cerebral circulation insufficiency(CCCI).Methods Fifty patients diagnosed as CCCI were assigned in test group,while 50 healthy subjects and 50 cerebral infarction cases served as two control groups.Each case was given carotid color Doppler examination and TCD to measure related indexes.Results In the test group,incidence of carotid atherosclerosis plaque,carotid intimal medial thickness(IMT) >1.0 mm,car...