PVEP在屈光参差性弱视和急性球后视神经炎鉴别诊断中的应用

目的：分析同年龄段屈光参差性弱视和急性球后视神经炎的图形视觉诱发电位（ PVEP）的P100波特征，为诊断弱视和急性球后视神经炎的鉴别提供依据。方法回顾性研究对2013年1月到2015年2月到我院门诊的弱视、急性球后视神经炎和正视眼，对三组PVEP的幅值和峰时进行两两比较。结果 PVEP检查发现：（1）弱视在1°空间频率时幅值（12．82±6．03）μV、峰时为（101．81±5．24） ms；在15′空间频率时幅值（10．31±3．51）μV、峰时为（113．13±5．99）ms。（2）急性球后视神经炎在1°空间频率时幅值（7．63±3．74）μV、峰时为（119．93±15.62）ms；在15′空间频率时幅值（6．19±4．18）μV、峰时为（125．00±11．75）ms。（3）正视眼在1°空间频率时幅值（11．36±2．05）μV、峰时为（97．71±3．77）ms；在15′空间频率时幅值（14．17±3．09）μV、峰时为（104．43±3．50） ms。弱视在1°空间频率时，P100波幅值和峰时同正常眼比较，差异无统计学意义，余各组两两比较差异均有统计学意义（ P ＜0．05）。结论 PVEP的P100波有助于鉴别屈光参差性弱视和急性球后视神经炎：屈光参差性弱视的的P100波幅值降低和峰时延迟主要表现在15′空间频率；急性球后视神经炎的P100波在1°和15′时，均有幅值降低和峰时延迟，且较弱视更严重。

Pattern visual evoked potentials in anisometropia amblyopia and acute retrobulbar neuritis

Objective To evaluate the differences in pattern visual evoked potentials ( P100 waves) between ambly-opia and acute retrobulbar neuritis in order to provide electrophysiological evidences for the diagnosis of amblyopia and a-cute retrobulbar neuritis.Methods This was a retrospective study.PVEP was performed in 14 eyes of 14 amblyopic a-dults, 15 eyes of 11 patients with acute retrobulbar neuritis and 14 eyes of 14 healthy individuals.Amplitude and latencies of P100 waves were analyzed and compared among groups.Results In the patients with retrobulbar neuritis, the amplitude (μvolt) was 7.63 ±3.74 at 1°temporal frequency (TF) an 6.19 ±4.18 at 15’ TF and the latencies were 119.93 ±15.62 ms and 125.00 ±11.75 respectively.In amblyopic patients, the amplitude was 12.82 ±6.03 at 1°TF and 10.31 ±3.51 at 15’ TF, and the latencies were 101.81 ±5.24 and 113.13 ±5.99 ms, respectively.Normal individuals had higher am-plitude (11.36 ±2.05 at 1°TF and 14.17 ±3.09 at 15’ TF) and shorter latencies (97.71 ±3.77 at 1°TF and 104.43 ±3.50 at 15’ TF).The differences in both amplitude and latency among the groups were significant ( P <0.05) except when compare both parameters at 1°TF in amblyopic patients versus in healthy subjects.Conclusion P100 measured in amblyopic patients showed decreased amplitude and prolonged latency at 15 ’ TF.In patients with retrobulbar neuritis, these changes were found at both 15’ TF and 1°TF, and were more profound than in amblyopic patients.