HP感染与胃癌发生部位、分类及分期分析

目的 近年来研究证实幽门螺杆菌(HP)感染参与了胃癌的发生发展。本研究分析HP感染与胃癌发生部位和分类及分期的关系。方法采用回顾性分析183例确诊为胃癌、并施行胃癌根治术患者的胃癌样本,根据Lauren及Lauren分型；病理组织切片,经HE和Giemsa染色,观察HP感染。结果183例胃恶性肿瘤中,胃腺癌168例(91.8％),淋巴瘤11例(6％),平滑肌肉瘤2例(1.0％),胃肠间质瘤(GIST)1例(0.5％)和卡波西肉瘤1例(0.5％)。胃癌患者中,病变55.4％发生在胃窦,21.4％发生在胃体,14.3％在胃底(P值=0.018)；肠型胃癌占65％,弥漫型胃癌占24.8％,混合型10.2％；69.6％有HP感染(肠型64％,弥漫型33％,混合型10％,P值=0.327)。结论胃窦癌、胃体癌及胃底癌组间HP感染率存在差异,提示HP感染可能与胃癌发生部位有关。

Relationship between Helicobacter pylori and histologicalsubtype,location of gastric cancer

Objective In recent years,studies have confirmed that Helicobacter pylori (HP) infection is involved in the development of gastric cancer (GC).This study analyzed the relationship between HP infection and the location and classification of gastric cancer and staging.MethodsRetrospective analysis of 183 cases of gastric cancer patients implemented radical gastrectomy,Gastric cancer samples were classified according to Lauren and Lauren.Pathological sections were stained with HE and Giemsa to observe HP infection.ResultsOf the 183 cases of gastric malignancy,168 cases (91.8%) of gastric adenocarcinoma,11 cases (6%) of lymphoma,2 cases (1.0%) of leiomyosarcoma,1 case of gastrointestinal stromal tumor (GIST) % And Kaposi ''s sarcoma in 1 case (0.5%).168 cases of GC patients,the average age of 67 years,60% of men.55.4% occurred in the gastric antrum,21.4% occurred in the gastric body,14.3% in the stomach (P=0.018); gastrointestinal cancer accounted for 65%,diffuse type gastric cancer accounted for 24.8%,mixed 10.2%; 69.6% were infected by HP (64% intestine,33% diffuse,10% mixed,P=0.327).ConclusionThere is a difference in HP infection rate between gastric antrum cancer,gastric cancer and gastric cancer group,suggesting that HP infection may be related to the occurrence of gastric cancer.