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| 局部应用辛伐他汀对拔牙窝内VEGFmRNA表达的影响及意义 | |
| 引用本文： | 方鸿满,刘畅,吴哲,许莹莹,赵磊,孙宏晨.局部应用辛伐他汀对拔牙窝内VEGFmRNA表达的影响及意义[J].口腔医学研究,2010,26(1):4-6. |
| 作者姓名： | 方鸿满 刘畅 吴哲 许莹莹 赵磊 孙宏晨 |
| 作者单位： | 1. 武警吉林省总队医院口腔科,吉林,长春,130052 2. 吉林大学口腔医院正畸科 3. 吉林大学口腔医院修复科 4. 吉林大学口腔医院病理科 |
| 基金项目： | 国家自然科学基金项目(编号:30872912) |
| 摘 要： | 目的：探讨局部应用辛伐他汀促进拔牙术后牙槽骨修复机制。方法：选用健康雄性Wistar大鼠56只，随机分为实验组28只和对照组28只，拔除右下颌中切牙后，实验组即刻植入载辛伐他汀PLGA支架材料，对照组植入单纯PLGA作为对照，于术后5d、1周、2周和4周分别处死大鼠，设计针对VEGFmRNA的寡核苷酸探针，采用原位杂交技术检测拔牙窝VEGFmRNA的表达。结果：术后1周和2周实验组VEGF阳性细胞数和染色强度均高于对照组，且差异有统计学意义，而术后4周，实验组和对照组阳性细胞数无统计学差异，且阳性表达细胞少于术后2周。结论：局部应用辛伐他汀通过增加VEGFmRNA的表达促进拔牙窝骨损伤的愈合。 |
| 关 键 词： | 辛伐他汀 牙槽骨VEGF mRNA |
Effects of Simvastatin on VEGF mRNA Expression of the Alveolar Bone following Tooth Extraction. |
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| FANG Hong-man,LIU Chang,WU Zhe.Effects of Simvastatin on VEGF mRNA Expression of the Alveolar Bone following Tooth Extraction.[J].Journal of Oral Science Research,2010,26(1):4-6. | |
| Authors: | FANG Hong-man LIU Chang WU Zhe |
| Institution: | FANG Hong-man,LIU Chang,WU Zhe. Department of Stomatology,Armed Police Hospital of Jilin Province,Changchun 130052 |
| Abstract: | Objective:To investigate the mechanism of topically used Simvastatin on promoting alveolar bone repair following tooth extraction. Methods:Fifty eight male Wistar rats were divided into experimental groups and control groups (28 rats/group). PLGA scaffold was immediately implanted with or without Simvastatin in extraction sockets of the mandibular incisors. Hybridization technique was conducted after 5days,1weeks,2weeks and 4weeks. Results:The number of VEGF-positive vascular endothelial cells in experiment... |
| Keywords: | Simvastatin Alveolar bone VEGF mRNA |
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