老年高血压患者合并腔隙性脑梗死与胰鸟素抵抗的关系

目的研究高血压合并腔隙性脑梗死与胰岛素抵抗（IR）的关系。方法将65例老年高血压合并脑梗死患者按照梗死灶直径分为腔隙性脑梗死组和非腔隙性脑梗死组，测定空腹血糖、胰岛素、血脂，计算胰岛素敏感指数（ISI），并与30例健康对照者进行比较。结果高血压合并脑梗死病人血脂、胰岛素、ISI与对照组比较，差异有统计学意义（P〈0．05），腔隙性脑梗死组胰岛素明显高于非腔隙性脑梗死组（P〈0．05），腔隙性脑梗死组ISI较非腔隙性脑梗死组明显减低（P〈0．05）。结论高血压合并脑梗死存在胰岛素抵抗，胰岛素抵抗可能是独立危险因素之一，腔隙性脑梗死可能直接与IR有关。

Correlation between Hypertension Combined with Lacuna Cerebral Infarction and Insulin Resistance

[Objective]To explore the correlation between hypertension combined with lacuna cerebral infarction and insulin resistance.[Methods] 65 patients with hypertension combined with lacuna cerebral infarction were divided into lacuna infarction group and non-lacuna infarction group;their fasting plasma glucoses,serum insulin,serum blood lipid were measured and there insulin sensitivity indexes(ISI) were calculated and compared with that of the control group.[Results] The blood lipid,insulin and ISI of the lacuna infarction group were significantly different from that of the control group(P<0.05).The insulin level of the lacuna infarction group was significantly higher than that of the control group(P<0.05);while ISI of the case group was significantly lower than that of the control group(P<0.05).[Conclusion]Insulin resistance exists in hypertension combined with lacuna cerebral infarction,it might be one of the individual risk factors;lacuna cerebral infarction might has direct correlation with IR.