Delayed effects of long-term administration of granulocyte colony-stimulating factor to mice |
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Authors: | I N Nifontova D A Svinareva I L Chertkov N I Drize V G Savchenko |
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Institution: | (1) Department of Bone Marrow Transplantation, Russian Academy of Medical Sciences, Moscow, Russia;(2) Laboratory for Physiology of Hemopoiesis, Research Center for Hemology, Russian Academy of Medical Sciences, Moscow, Russia |
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Abstract: | We studied the effects of chronic administration of granulocyte colony-stimulating factor in nonmobilizing doses to mice.
Over 18 months of the study, 55% animals of the treatment group died of unknown cause, blood diseases and tumors were found
in 20% mice, and in 5% animals pathological changes were absent. Control mice had no diseases (normal values of total and
differential leukocyte count). The diagnoses made over the first 7 months mainly included myeloproliferative diseases. Solid
tumors were found at later terms. Suppurative inflammation at the site of injection was observed in all mice after 3-month
treatment with granulocyte colony-stimulating factor. Our results indicate that chronic administration of granulocyte colony-stimulating
factor in low doses leads to the development of etiologically different tumors and sharply reduced animal life span. The use
of granulocyte colony-stimulating factor during allogeneic transplantation of hemopoietic stem cells can be hazardous for
donors.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 5, pp. 568–573, May, 2008 |
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Keywords: | granulocyte colony-stimulating factor hemopoietic stem cells myeloproliferation tumor transformation |
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