Mice lacking D-amino acid oxidase activity display marked attenuation of stereotypy and ataxia induced by MK-801 |
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| Authors: | Hashimoto Atsushi Yoshikawa Masanobu Niwa Akira Konno Ryuichi |
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| Affiliation: | Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa 259-1143, Japan. hashimoto@is.icc.u-tokai.ac.jp |
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| Abstract: | The behavioral effects produced by MK-801 (0.4 mg/kg) were compared in mutant DAO-/- mice lacking D-amino acid oxidase activity and normal DAO+/+ mice. Mutant mice display marked diminution of stereotypy and ataxia induced by MK-801 compared to normal mice. Because the D-serine level in the brain of mutant mice is significantly higher than that of normal mice, the elevated D-serine in the brain of mutant mice could antagonize MK-801-induced stereotypy and ataxia. |
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| Keywords: | Neurotransmitters modulators transporters and receptors Excitatory amino acids: physiology pharmacology and modulation |
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