Cytokine levels during mild and cerebral falciparum malaria in children living in a mesoendemic area |
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Authors: | João Luís Baptista Guido Vanham Marc Wéry & Eric Van Marck |
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Institution: | Laboratory of Protozoology, Department of Parasitology, Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium;Laboratory of Immunology, Department of Microbiology, Prince Leopold Institute of Tropical Medicine, Antiverp, Belgium;Department of Pathology, University of Antwerp, Belgium. |
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Abstract: | Summary Cell-mediated immunity and cytokines are probably involved in the pathogenesis of malaria. To investigate the role and the activity of different immune cells, we measured levels of tumour necrosis factor-(TNF-α), gamma interferon (IFN-γ) and several interleukins (IL-2, IL-4, IL-6 and IL-10) in children with mild (MM) and cerebral (CM) Plasmodium falciparum malaria and compared them with those of healthy children from Guadalupe - Lobata District, St. Tomé Island, where malaria is mesoendemic. Both groups of patients had significantly higher levels of IL-6, IL-10 and TNF-α than controls. For IL-2, IL-4 and IFN-γ we found no difference between the groups. However, 24 h after admission the levels of IL-10 and IL-6 were significantly higher in CM than in MM patients, although 7 days after treatment they returned to normal levels, similar to those found in control children. Therefore, TNF-α IL-6 and IL-10 increase during Plasmodium falciparum attacks in all children, not only in those with cerebral malaria. This finding suggests the activation of the monocyte/macrophage system during the early stage of clinical malaria. |
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Keywords: | cytokines Plasmodium falciparum mild malaria cerebral malaria St Tomé Island |
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