| 家犬在大剂量芥子气全身吸收中毒实验治疗后的病理观察 |
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| 引用本文： | 刘振华,刘贵祥,宋杰军,毛坚跃,葛礼勤. 家犬在大剂量芥子气全身吸收中毒实验治疗后的病理观察[J]. 第二军医大学学报, 1985, 0(5) |
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| 作者姓名： | 刘振华 刘贵祥 宋杰军 毛坚跃 葛礼勤 |
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| 作者单位： | 第二军医大学病理解剖学教研室(刘振华)，第二军医大学医学防护教研室(刘贵祥，宋杰军，毛坚跃)，第二军医大学医学防护教研室(葛礼勤) |
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| 摘 要： | 以30只健康雄性狗作大剂量(24mg/kg LD)芥子气全身吸收中毒后实验性治疗,采用了四种治疗方案,并做病理观察。实验结果以第Ⅲ治疗方案最好,存活率达90.9％。 病理组织学观察支持临床治疗效果,突出表现在小肠粘膜上皮、脾、淋巴结、骨髓、肾上腺及睾丸等组织,在中毒后治疗均于2周内基本恢复再生。 此研究尚提供一些临床值得进一步探讨的问题,如免疫功能的恢复、肾上腺皮质功能的改变等,并为进一步改善治疗方案提供组织学依据。
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| 关 键 词： | 芥子气 中毒 病理学 |
A PATHOLOGIC OBSERVATION OF EXPERIMENTAL THOERAPIES AFTER LETHAL DOSE MUSTURD GAS POISONING IN DOGS |
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| Liu Zhenhua,et al. A PATHOLOGIC OBSERVATION OF EXPERIMENTAL THOERAPIES AFTER LETHAL DOSE MUSTURD GAS POISONING IN DOGS[J]. Former Academic Journal of Second Military Medical University, 1985, 0(5) |
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| Authors: | Liu Zhenhua et al |
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| Affiliation: | Department of Pathology |
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| Abstract: | Thirty male dogs poisoned by lethal dose (21 mg/kg LD) of musturd gas were treated by 4 kinds therapeutic programs and observed by pathological examinations.The results showed that the 3rd therapeutic program was the best one.The survival rate of dogs reached 90.9%.The clinical therapeutic effects were supported by histopathological observation. The mucous epithelia of small bowel, spleen, lymph nodes, bone marrow, adrenal glands and testes, all of these tissues and organs were predominantly restord and regenerated after the 3rd therapeutic program treatment within 2 weeks.However, some problems require further research such as the restoration of immune function and the cortical functional changes of adrenal glands.Observations supplied histopathological evidences to improve further therapeutic program. |
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| Keywords: | musturd gas poisoning pathology |
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