Quercetin reduces the elevated matrix metalloproteinases-9 level and improves functional outcome after cerebral focal ischemia in rats |
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| Authors: | Lee Jung-Kil Kwak Hyung-Jun Piao Min-Sheng Jang Jae-Won Kim Soo-Han Kim Hyung-Seok |
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| Affiliation: | (1) Department of Neurosurgery, Chonnam National University Medical School and Hospital, 8 Hak-dong, Dong-ku, Gwangju, 501-757, Republic of Korea;(2) Clinical Trial Center, Chonnam National University Hospital, Gwangju, South Korea;(3) Department of Forensic Medicine, Chonnam National University Medical School, Gwangju, South Korea |
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| Abstract: | Background Blood–brain barrier (BBB) disruption mediated by matrix metalloproteinase (MMPs) activation is a critical event during cerebral ischemia. The inhibition of MMP might be a potential approach to protect against secondary injury. The present study was designed to determine the effects of quercetin on BBB disruption and MMP activity, in a focal ischemia model induced by photothrombosis, in rats. |
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