The Relationship Between the Genetic and Environmental Influences on Common Internalizing Psychiatric Disorders and Mental Well-Being |
| |
Authors: | Email author" target="_blank">Kenneth?S?KendlerEmail author John?M?Myers Hermine?H?Maes Corey?L?M?Keyes |
| |
Institution: | (1) Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, P.O. Box 980126, 800 E. Leigh Street, Room 1-123, Richmond, VA 23298-0126, USA;(2) Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, VA, USA;(3) Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA;(4) Department of Sociology, Emory University, Atlanta, GA, USA |
| |
Abstract: | To determine the relationship between the genetic and environmental risk factors for common internalizing psychopathology
(IP) and mental well-being (MWB), we examined detailed measures of emotional, social and psychological well-being, and a history
of major depression (MD), generalized anxiety disorder (GAD) and panic attacks in the last year, in 1,386 twins from same-sex
pairs from the MIDUS national USA sample assessed in 1995 and then again in 2005. Statistical analyses were performed with
the Mx program. In the 1995 data, the best fit model contained one substantially heritable common factor for MD, GAD and panic
attacks, and one strongly heritable common factor for the three well-being measures. Genetic and environmental risk factors
for IP accounted for, respectively, 50 and 5%, of the genetic and environmental influences on MWB. We then constructed, using
1995 and 2005 data, two common factors that reflected temporally stable influences on (i) MD and GAD, and (ii) on emotional
and psychological well-being. Genetic and environmental risk factors for the stable liability to IP accounted for 41 and 29%
of the stable genetic and environmental influences, respectively, on MWB. This study suggests that genetic risk factors for
IP make up 41–50% of the genetic influences on MWB. The overlap of environmental risk factors is more modest. Although low
levels of IP on average reflect a high genetic propensity for MWB, other independent genetic influences play an important
role in producing good mental health. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|