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Transforming growth factor beta-1 (TGFB1) and peak bone mass: association between intragenic polymorphisms and quantitative ultrasound of the heel
Authors:Peter?Tzakas,Betty?YL?Wong,Alexander?G?Logan,Laurence?A?Rubin,David?EC?Cole
Affiliation:(1) Dept. of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada;(2) Dept. of Clinical Pathology, Sunnybrook and Women's College Health Sciences Centre, Toronto, ON, Canada;(3) Prosserman Centre for Health Research, Mount Sinai Hospital, Toronto, ON, Canada;(4) Dept. of Medicine, University of Toronto, Toronto, ON, Canada;(5) Dept. of Rheumatology, St Michael's Hospital, Toronto, ON, Canada;(6) Dept. of Paediatrics (Genetics), University of Toronto, Toronto, ON, Canada
Abstract:

Background  

Variance of peak bone mass has a substantial genetic component, as has been shown with twin studies examining quantitative measures such as bone mineral density (BMD) and quantitative ultrasound (QUS). Evidence implicating single nucleotide polymorphisms (SNPs) of the transforming growth factor beta-1 (TGFB1) gene is steadily accumulating. However, a comprehensive look at multiple SNPs at this locus for their association with indices of peak bone mass has not been reported.
Keywords:
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