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Assessment of HIV-1 entry inhibitors by MLV/HIV-1 pseudotyped vectors

Authors:	Sandra?Siegert,Sonja?Thaler,Ralf?Wagner,Barbara?S?Schnierle author-information" > author-information__contact u-icon-before" > mailto:schba@pei.de" title=" schba@pei.de" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Georg-Speyer-Haus, Institute for Biomedical Research, Paul-Ehrlich-Strasse 42-44, D-60596 Frankfurt am Main, Germany;(2) Paul-Ehrlich Institute, Abt. 2/01, Paul-Ehrlich Strasse 51-59, D-63225 Langen, Germany;(3) Department of Medicine III, Johannes Gutenberg University, 55101 Mainz, Germany;(4) Institute of Medical Microbiology and Hygiene, University of Regensburg, Franz-Josef-Strauss Allee 11, 93053 Langen, Regensburg;(5) Friedrich Miescher Institute, Maulbeerstrasse 66, CH-4058 Basel, Switzerland

Abstract:	Background Murine leukemia virus (MLV) vector particles can be pseudotyped with a truncated variant of the human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) and selectively target gene transfer to human cells expressing both CD4 and an appropriate co-receptor. Vector transduction mimics the HIV-1 entry process and is therefore a safe tool to study HIV-1 entry.

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