肝细胞生长因子与基质金属蛋白酶-2在子宫内膜异位症在位子宫内膜的表达及意义

目的:探讨肝细胞生长因子(HGF)及基质金属蛋白酶2(MMP2)与子宫内膜异位症发病机理的关系。方法:采用链霉素抗生物素蛋白过氧化物酶(SP)法检测45例盆腔子宫内膜异位症妇女(实验组)及30例非子宫内膜异位症妇女(对照组)的在位子宫内膜的HGF与MMP2的免疫表达水平。结果:盆腔子宫内膜异位症妇女在位子宫内膜的HGF与MMP2表达水平均高于对照组,差异有显著性(P均<0.01),且两者均呈正相关(实验组r=0.902,对照组r=0.949)。结论:类似肿瘤的转移和入侵机制,HGF及MMP2与子宫内膜异位症的发病有关。

Expression and Significance of HGF and MMP-2 in the Eutopic Endometrium of Endometriosis

Objective: To investigate the relationship of the hepatocyte growth factor (HGF) and matrix metalloproteinase-2(MMP-2) with the pelvic endometriosis. Methods: The Streptavidin-Peroxidase (S-P) immunohistochemical method was used to detect the immunoexpression of HGF and MMP-2 in the eutopic endometrium of forty five women with pelvic endometriosis and thirty women without endometriosis. Results: The immunoexpression of HGF and MMP-2 were markedly higher in the eutopic endometrium of patients with pelvic endometriosis than that of the controls(P<0.01). A positive correlation between the immunoexpression of HGF and MMP-2 was also observed (r=0.902 in the endometriosis group; r=0.949 in the control group). Conclusion: In a manner analogous to tumour metastasis and invasive mechanism, HGF and MMP-2 may be involved in the pathogenesis of endometriosis.