苯那普利对兔髂动脉球囊损伤后内膜增生的影响

为了探讨髂动脉内膜剥脱术后再狭窄的预防，将２８只兔随机分为苯那普利组和对照组，行右髂动脉内膜球囊剥脱术。术后３０天处死动物，作病理形态学检查及流式细胞术测定。结果表明，苯那普利组损伤血管内膜厚度小于对照组，而管腔面积大于对照组（Ｐ均＜０．００１）。治疗组血管壁细胞增殖期细胞数明显低于对照组（Ｐ均＜０．００１）。提示，苯那普利能抑制动脉球囊损伤后血管平滑肌细胞增殖，减轻内膜增生。

Effect of Lotension on Intimal Proliferation after Baloon Injury of Rabbit Iliac Artery

In order to study the prevention of restenosis after illac arterial endothelial debridement, 28 rabbits were randomized into two groups. In the treatment group( n =14), Lotension 10 mg/d was taken orally from 7 days before to 30 days afer endothelial debridement. In control group( n =14), no Lotension was taken. All rabbits underwent endothelial debridement of the right iliac artery and were killed 30 days later. Pathomorphological examination and flow cytometry were carried out. The result demonstrated that Lotension significantly reduced the thickness of iliac arterial intima and increased the luminal cross sectional area of the arteries compared with the control group(all P <0.001). It also showed that the number of proliferous cells of the arterial wall in the treatment group was significantly lower than that in the control group (all P <0.001). In conclusion, Lotension could effectively inhibit the hyperplasia of smooth muscle cells in the arterial intima and significantly reduced intima thickness.