| 碱性成纤维细胞生长因子在下颌骨缺损愈合中的作用 |
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| 引用本文： | 王元银,王银龙,何家才,周健,陈乔尔,程继光,叶金海. 碱性成纤维细胞生长因子在下颌骨缺损愈合中的作用[J]. 安徽医科大学学报, 2001, 36(4): 275-276 |
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| 作者姓名： | 王元银 王银龙 何家才 周健 陈乔尔 程继光 叶金海 |
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| 作者单位： | 安徽医科大学附属口腔医院, |
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| 基金项目： | 安徽省教育厅科研项目;98J1067; |
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| 摘 要： | 目的 研究碱性成纤维细胞生长因子在颌骨缺损愈合中的作用。方法 在12只杂种狗中制作下颌骨缺损模型并分别植bFGF 自体髓和bFGF bBMP，并设置空白对照组，植入后2、4、8、12周作组织学观察骨缺损区新骨形成情况。结果 早期成纤维细胞生长因子复合物成骨更好、较单纯对照成骨好，但到8周后，所有实验组成骨无明显差异。结论 成纤维细胞生长因子能有效地促进成骨。
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| 关 键 词： | 碱性成纤维细胞生长因子 骨基质 下颌骨损伤 bFGF bBMP 动物模型 |
| 文章编号： | 1000-1492(2001)04-0275-02 |
| 修稿时间： | 2001-04-20 |
The effect of fibroblast growth factor in the mandibular defect |
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| Wang Yuanyin,Wang Yinglong,He Jiacai et al. The effect of fibroblast growth factor in the mandibular defect[J]. Acta Universitis Medicinalis Anhui, 2001, 36(4): 275-276 |
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| Authors: | Wang Yuanyin Wang Yinglong He Jiacai et al |
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| Abstract: | Objective To study the effect of basic fibroblast growth factor on healing mandibular defect. Methods 12 beagle dogs with mandibular defect were classified into three groups to implant with various graft bFGF bone formation, bFGF bBMP and no implant as control group. At 2, 4, 8 and 12 weeks after operation, the effect of defect repair were observed by histological analysis. Results Before 8 weeks, the composite consisting of bFGF stimulated more bone formation than of no implant as control group. At 8 weeks after operation, all experimental groups bone formation showed no significant difference. Conclusion bFGF is a promising bone substitute in clinical uses. |
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| Keywords: | fibroblast growth factor basic bone matrix mandibular injuries |
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