McAbGB2识别的乳腺癌血清抗原水平观察

为探明乳腺癌患者由ＭｃＡｂＧＢ２识别的乳腺癌血清抗原水平，应用ＥＬＩＳＡ方法，用抗人乳腺癌血清抗原ＭｃＡｂＧＢ２观察了５０例正常人和６０例乳腺癌患者血清ＭｃＡｂＧＢ２抗原水平。结果；１７例乳腺癌患者术前的血清ＭｃＡｂＧＢ２抗原水平与正常人之间有显著性差异，其阳性符合率达８８．２％。

Detection of the level of serum antigen recognized by McAbGB2 in breast cancer]

This study sought to verify the levels of serum antigen recognized by McAbGB2 (abbr. serum McAbGB2 antigen) in patients with breast cancer. We adopted the ELISA method and used McAbGB2 to detect the level of serum McAbGB2 antigen in 50 normal persons and 60 patients with breast cancer. The results showed that the level of serum McAbGB2 antigen of 17 preoperative patients with breast cancer was significantly different from that of the normal persons (P < 0.001); the rate of agreement on positivity for the 17 preoperative patients with breast cancer was 88.2% (15/17); the levels of serum McAbGB2 antigen in 8 patients among the 17 preoperative patients with breast cancer decreased from 57.5 +/- 51.3 u/ml (preoperation) to 20.6 +/- 4.98 u/ml (postoperation; the levels of serum McAbGB2 antigen in the other 43 operated patients with breast cancer almost remained normal during post-operative chemotherapy. These suggest that serum McAbGB2 antigen is a marker for breast cancer and can be used for serological diagnosis, treatment and prognosis inspection.