| 急性白血病患儿外周血白血病细胞转铁蛋白受体表达分析 |
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| 引用本文： | 黄贵清,廖清奎.急性白血病患儿外周血白血病细胞转铁蛋白受体表达分析[J].华西医科大学学报,1997,28(1):55-57. |
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| 作者姓名： | 黄贵清 廖清奎 |
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| 摘 要： | 为研究铁在白血病细胞增殖过程中的作用,采用受体放射性配体结合分析法测定２０例急性淋巴细胞性白血病和９例急性髓系白血病患儿外周血白血周细胞上的转铁蛋白受体结合位点数。结果显示ＡＭＬ明显高于ＡＬＬ组（Ｐ〈０．０５）,两组内死亡,复发组均高于完全缓解组（Ｐ〈０．０５）,提示Ｔｆｒ与白血病预后有关。
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| 关 键 词： | 白血病 急性 转铁蛋白受体 预后 儿童 |
An analysis of acute leukemia cells TfR expression in children] |
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| G Huang,Q Liao,C Luo,F Li,R Fu.An analysis of acute leukemia cells TfR expression in children][J].Journal of West China University of Medical Sciences,1997,28(1):55-57. |
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| Authors: | G Huang Q Liao C Luo F Li R Fu |
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| Institution: | Lab of Pediatrics Hemology and Oncology, Second Affiliated Hospital, Chengdu. |
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| Abstract: | There are a lot of transferrin receptors on the acute leukemia cells. We used the method of "Receptor Radioligand Assay" to determine the numbers of TfR binding sites on leukemia cells from 20 child patients with acute lymphocyte leukemia (ALL) and 9 with acute myeloid leukemia (AML). The results showed the numbers of TfR binding sites of AML cells were higher than those of ALL cells, and the numbers of complete remission group were lower than those of dead or relapse group. This indicated there might be a relationship between the TfR expression and the prognosis. |
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