嗜酸性粒细胞性胃肠炎1例报道并文献复习

目的:总结嗜酸性粒细胞胃肠炎(EG)的分型、临床表现、诊断及治疗方法。方法:1例以反复出现消化道症状入院患儿, 入院后完善相关检查,排除寄生虫感染、血液系统肿瘤等疾病, 确诊为EG, 给予抗过敏药物、白三烯抑制剂及皮质激素治疗。观察患儿临床症状缓解及消失、实验室指标恢复正常的时间。结果:EG有反复出现呕吐、腹痛、腹泻等消化道症状, 甚至出现吞咽困难、肠梗阻、肠穿孔;实验室检查:外周血嗜酸性粒细胞升高;内镜检查:黏膜粗糙、充血水肿, 点片状红斑或糜烂;活组织病理检查:病变部位每高倍视野超过15~20个嗜酸性粒细胞。皮质激素等治疗后, 实验室指标逐渐恢复正常, 临床症状好转直至消失。结论:EG是一种胃肠道变态反应性良性疾病, 皮质激素治疗有效。

The eosinophilic gastroenteritis complicated in a case and literature review

Objective:To summary the genotyping,clinical manifestations,diagnosis and clinical treatment of eosinophil gastroenteritis ( EG) . Methods:One EG child with recurrent gastrointestinal symptoms,excluding parasitic infections,blood system cancer and other diseases,was dignosed by examination, who was treated with anti-allergic drugs, leukotriene inhibitor and corticosteroid. The time of clinical symptoms remission and disappear, and laboratory index recovery were observed. Results:The recurrent vomiting, abdominal pain,diarrhea and other gastrointestinal symptoms, even dysphagia, intestinal obstruction and intestinal perforation, were the clinical features of EG. The laboratory test showed that eosinophilia granulocyte of peripheral blood increased. The rough mucosal congestion and edema,and point flake erythema or erosion were found by endoscopic examination. Fifteen to twenty eosinophils per high power field of the lesion were identified by pathology examination. The laboratory parameters returned to normal level,and clinical symptoms improved or disappeared after treatment. Conclusions:EG is a gastrointestinal allergic benign disease, the effect of which treated with corticosteroid is effective.