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Apolipoprotein E genotype and neurodevelopmental sequelae of infant cardiac surgery |
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| Authors: | Gaynor J William Gerdes Marsha Zackai Elaine H Bernbaum Judy Wernovsky Gil Clancy Robert R Newman Mark F Saunders Ann M Heagerty Patrick J D'Agostino Jo Ann McDonald-McGinn Donna Nicolson Susan C Spray Thomas L Jarvik Gail P |
| Institution: | Division of Cardiothoracic Surgery, The Children's Hospital of Philadelphia, PA 19104, USA. gaynor@email.chop.edu |
| Abstract: | BACKGROUND: There has been increasing recognition of adverse neurodevelopmental sequelae in some children after repair of congenital heart defects. Even among children with the same cardiac defect, significant interindividual variation exists in developmental outcome. Polymorphisms of apolipoprotein E have been identified as a risk factor for worse neurologic recovery after central nervous system injury. METHODS: A single-institution prospective study of patients |
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