实验高压电烧伤后肝脏微循环动态变化及意义

目的通过研究高压电烧伤后动物肝脏微循环的变化，探讨高压电对肝脏微循环的影响。方法将20只家兔随机分为高压电烧伤组（实验组）和假高压电烧伤组（对照组），每组各10只。用实验高压电击系统复制家兔高压电烧伤模型，采用WX-9B型多部位微循环显微镜及其图像分析系统，观察高压电烧伤后肝脏表面微血管形态、微血流动态及微血管周围状态的早期变化及规律。结果实验组伤后即刻终末门微静脉、中央静脉和肝窦收缩，肝窦清晰度下降，血流速度减慢；伤后1h上述微血管扩张，肝窦变清晰，血流速度恢复正常；伤后2～6h再度出现上述微血管收缩，肝窦密度减低，血流速度下降等变化，并呈逐渐加重趋势。实验组伤后即出现红细胞聚集、白细胞附壁、微血栓、渗出和出血等改变，并呈逐渐加重趋势。结论高压电烧伤可引起家兔肝脏微循环障碍。

Dynamic Alteration and Significance of Hepatic Microcirculation After High-voltage Electric Burn

Objective To study the effect of electrical injury on hepatic microcirculation by observing the changes of hepatic microcireulation（HMC） of rabbits with high-voltage electric burn（HEB）. Methods 20 adult healthy rabbits were randomly divided into two groups, namely, electrical burned group and fake electrical burned group, 10 in each group. After a model of high-voltage electric burn was duplicated, hepatic microvascular morphology, microvascular blood flow state and microvascular periphery state were observed with WX- 9B Poly-position microeirculation instrument. Results The terminal portal venule, central vein and sinusoid contracted the moment after burning, the distinctness of sinusoid reduced and the rate of blood flow decreased. lhours after HEB, microvessel dilated and sinusoid became distinct, the rate of blood flow recovered to normal level. From 2h to 6h after HEB, microvessel contracted again, the density of sinusoid reduced and the rate of blood flow decreased, which became serious as time went by. The moment after burning, erythrocyte aggregation, leukocyte attachment, microthrombus, peripheral exudation and hemorrhagia could be seen and became serious gradually. Conclusion HEB can induce the disturbance of rabbit＇ s hepatic microcireulation.