Physiologic characterization of inflammatory arthritis in a rabbit model with BOLD and DCE MRI at 1.5 Tesla |
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Authors: | Otilia C Nasui Michael W Chan George Nathanael Adrian Crawley Elka Miller Jaques Belik Hai-Ling Cheng Andrea Kassner Tammy Rayner Ruth Weiss Garry Detzler Anguo Zhong Rahim Moineddin Roland Jong Marianne Rogers Andrea S Doria |
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Institution: | 1. Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada, M5G1X8 3. Department of Medical Imaging, University of Toronto, Toronto, ON, Canada 4. Department of Medical Imaging, Toronto Western Hospital, Toronto, ON, Canada 7. Department of Diagnostic Imaging, Children’s Hospital of Eastern Ontario (CHEO), Ottawa, ON, Canada 2. Department of Neonatology, The Hospital for Sick Children, Toronto, ON, Canada 5. Department of Public Health, Family and Community Medicine, Toronto, ON, Canada 6. Department of Pathology, Mount Sinai Hospital, Toronto, ON, Canada
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Abstract: | Objective Our aim was to test the feasibility of blood oxygen level dependent magnetic resonance imaging (BOLD MRI) and dynamic contrast-enhanced (DCE) MRI to monitor periarticular hypoxic/inflammatory changes over time in a juvenile rabbit model of arthritis. Methods We examined arthritic and contralateral nonarthritic knees of 21 juvenile rabbits at baseline and days 1,14, and 28 after induction of arthritis by unilateral intra-articular injection of carrageenin with BOLD and DCE MRI at 1.5 Tesla (T). Nine noninjected rabbits served as controls. Associations between BOLD and DCE-MRI and corresponding intra-articular oxygen pressure (PO2) and blood flow blood perfusion units (BPU)] (polarographic probes, reference standards) or clinical–histological data were measured by correlation coefficients. Results Percentage BOLD MRI change obtained in contralateral knees correlated moderately with BPU on day 0 (r?=??0.51, p?=?0.02) and excellently on day 28 (r?=??0.84, p?=?0.03). A moderate correlation was observed between peak enhancement DCE MRI (day 1) and BPU measurements in arthritic knees (r?=?0.49, p?=?0.04). In acute arthritis, BOLD and DCE MRI highly correlated (r?=?0.89, p?=?0.04; r?=?1.0, p?0.0001) with histological scores in arthritic knees. Conclusion The proposed techniques are feasible to perform at 1.5 T, and they hold potential as surrogate measures to monitor hypoxic and inflammatory changes over time in arthritis at higher-strength MRI fields. Key points ? BOLD and DCE MRI detect interval perisynovial changes in a rabbit knee ? BOLD and DCE MRI act as surrogate markers of physiologic changes in arthritis ? BOLD MRI signal represents oxygen extraction compared with intra-articular PO 2 ? DCE MRI measurements estimate physiologic periarticular vascular properties ? In rabbit knees with acute arthritis, BOLD/DCE MRI highly correlated with histological scores |
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