<Emphasis Type="Italic">Calcr</Emphasis>, a brain-specific imprinted mouse calcitonin receptor gene in the imprinted cluster of the proximal region of chromosome 6 |
| |
Authors: | Hidetoshi?Hoshiya Makiko?Meguro Akiko?Kashiwagi Chiga?Okita Email author" target="_blank">Mitsuo?OshimuraEmail author |
| |
Institution: | (1) Division of Molecular and Cell Genetics, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, 86 Nishimachi, Yonago 683-8503, Japan, |
| |
Abstract: | Expressed sequence tags (ESTs) in the human chromosome 7q21-q31 region were recently used to screen for allelic expression
bias in monochromosomal hybrids retaining a paternal or maternal human chromosome 7. Six candidate imprinted genes were identified.
In this study, we investigated parent-of-origin-specific expression profiles of their mouse homologues in the proximal region
of chromosome 6. An imprinting analysis, using F1 mice from reciprocal crosses between the B6 and JF strains, demonstrated
that the mouse calcitonin receptor gene (Calcr) was expressed preferentially from the maternal allele in brain, whereas no allelic bias was detected in other tissues. Our
results indicate that Calcr is imprinted in a tissue-specific manner, with a predominant expression from the maternal allele in the brain.
Electronic Publication |
| |
Keywords: | Genomic imprinting Parent-of-origin-specific expression Tissue-specific Calcitonin receptor Imprinted cluster |
本文献已被 PubMed SpringerLink 等数据库收录! |
|