无法切除的进展期胰腺癌血清VEGF-C蛋白含量与预后的关系

目的研究无法切除的进展期胰腺癌患者血清中VEGF-C蛋白含量与预后的关系。方法选择无法切除的进展期胰腺癌病例35例,记录入组时的年龄、肿瘤最大直径、肿瘤生长部位、KPS评分、血清CA19-9值,ELISA检测患者血清中VEGF-C蛋白含量。应用Kaplan-Meier法计算生存率,并绘制生存曲线,Log-rank法检验不同变量间生存率的差异,Cox回归模型进行预后的单因素分析和多因素分析。结果 35例胰腺癌患者血清中VEGF-C蛋白含量平均值为（1309.23±542.05）ng/L。Cox风险模型发现血清KPS评分、VEGF-C值及CA19-9值依次入选为无法切除的进展期胰腺癌患者预后影响因素。血清VEGF-C值≤1280 ng/L与〉1280 ng/L的两组病例,平均生存时间分别为11.26月与6.29月,1年累积生存率分别为50.0%与5.9%,组间差异有统计学意义（χ2=9.4000,P=0.0022）。结论无法切除的进展期胰腺癌患者,其VEGF-C血清蛋白含量值和预后存在一定关系,可作为预后判断的参考指标。

Correlation between serum concentration of VEGF-C and prognosis in patients with unresectable advanced pancreatic cancer

Objective To investigate the correlation between the serum concentration of VEGF-C and prognosis in patients with unresectable advanced pancreatic cancer.Methods Thirty-five patients with unresectable advanced pancreatic cancer were admitted from Aug.2006 to Feb.2008.The clinical data including age,karnofsky performance scale（KPS）,tumor size and serum concentration of CA19-9 were reviewed.The serum concentration of VEGF-C was detected by enzyme linked immunosorbent assay（ELISA）.Survival rate was analyzed by Kaplan-Meier method,univariance and multiplevariance analysis were performed by Cox regression.Results The mean serum concentration of VEGF-C was（1309.23±542.05）ng/L.In Cox regression,KPS,serum concentration of VEGF-C and CA19-9 were correlated with prognosis in unresectable pancreatic cancer.In groups of VEGF-C≤1 280 ng/L and 1 280 ng/L,the median survival was 11.26 and 6.29 months,the 1y-survival rates were 50.0% and 5.9%,respectively（χ2=9.4000,P=0.0022）.Conclusion The serum concentration of VEGF-C is correlated with prognosis of unresectable advanced pancreatic cancer.