改良大鼠弥漫性脑损伤实验模型

目的 改良弥漫性脑损伤动物模型,建立一种简单实用的闭合性弥漫性颅脑损伤动物模型.方法 改良marmarou打击装置建立大鼠弥漫性颅脑损伤动物模型,脑组织的病理学改变使用渡银染色及HE染色法检测.结果 损伤呈全脑局部弥漫性分布,有出血、神经细胞肿胀、胶质细胞嗜酸性变、脑组织疏松、神经细胞变性坏死、嗜神经现象.结论 改良的marmarou闭合性大鼠颅脑损伤模型可作为闭合性弥漫性颅脑损伤研究的病理实验基础.

Improved the rat model of diffuse brain injury

Objective To improve the rat model of diffuse brain injury and establish a simple and practical animal model to study closed diffuse brain injury. Methods The marmarou-brain injury model was improved. The morphological changes of brain injury was detected by routine histochemieal and silver staining. Results In the improved rat model diffuse heamorrhage were observed. Which included bleeding, swelling of nerve cells, glial cells eosinophilic change, loose brain tissue, nerve cell degeneration and necrosis, perineural phenomenon. Conclusions The improved marmarou-rat model could be used to study closed diffuse brain injury.