Effects of cognitive behavior therapy on regional brain volume in spider-phobic patients: Preliminary results |
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| Affiliation: | 1. Tianjin Key Laboratory of Process Measurement and Control, School of Electrical Engineering and Automation, Tianjin University, Tianjin, China;2. Department of Radiation Oncology, Stanford University School of Medicine, Palo Alto, California;1. Department of Psychology, University of Wyoming, 1000 E. University Avenue, Laramie, WY 82070, United States;2. Department of Psychology, University of Memphis, 202 Psychology Building, Memphis, TN 38152, United States;3. Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Box 356560, 1959 NE Pacific Street, Seattle, WA 98195, United States;1. University of Missouri-Columbia and the Midwest Alcoholism Research Center, Columbia, MO, USA;2. University of Minnesota, Minneapolis, MN, USA;3. Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA;4. Washington University School of Medicine and the Midwest Alcoholism Research Center, St. Louis, MO, USA;1. Aksaray State Hospital, Psychiatry Clinic, Aksaray 68100, Turkey;2. Hacettepe University Faculty of Medicine, Department of Psychiatry, Sıhhiye, Ankara 06100, Turkey;3. Aksaray Dentistry Hospital, General Dentistry Clinic, Aksaray 68100, Turkey;1. Hunter Holmes McGuire, Richmond VA Medical Center (116-B), 1201 Broad Rock Boulevard, Richmond, VA 23249, USA;2. Department of Psychology, Virginia Commonwealth University, 806 West Franklin Street, PO Box 842018, Richmond, VA 23284, USA;3. Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, 122 E. Marshall Street, 4th Floor, Box 980677, Richmond, VA 23298, USA;4. Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 East Leigh Street, Suite 101, Richmond, VA 23219, USA;5. VA Mid-Atlantic Region Mental Illness Research, Education and Clinical Center (MIRECC), 508 Fulton Street, Durham, NC 27705, USA;6. VA Center for Health Services Research in Primary Care, Durham NC 508 Fulton Street, Durham, NC 27705, USA;7. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 2301 Erwin Road, Durham, NC 27710, USA |
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| Abstract: | Successful cognitive behavior therapy (CBT) for spider phobia is able to change patients’ brain activation during visual symptom provocation. The present voxel-based morphometry study investigated whether this therapy approach can additionally affect brain structure. We analyzed gray matter volume of 12 spider-phobic patients prior to CBT and in a six-month follow-up investigation, and contrasted the results with data from 13 non-phobic controls. CBT provoked a dramatic decrease in syndrome severity in the clinical group as indexed by self-report and by a behavioral approach test. This was accompanied by a reduction of left supplementary motor area volume, which was correlated with the reduction of symptom severity. The therapy-related decrease of left amygdala volume was marginally significant. Nevertheless, in both sessions the patients were characterized by increased amygdala volume relative to controls. Our findings have to be considered preliminary and need replication in a bigger sample. |
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| Keywords: | Voxel-based morphometry Spider phobia Cognitive behavior therapy Amygdala |
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