Assessment of RANTES levels as the indicators of plaque vulnerability in rabbit models of atherosclerosis |
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| Affiliation: | 1. Pathology Department, Umraniye Education and Research Hospital, Istanbul, Turkey;2. General Surgery Department, Medeniyet University, Istanbul, Turkey;3. General Surgery Department, Umraniye Education and Research Hospital, Istanbul, Turkey;1. Department of Immunology, School of Basic Medical Sciences, Beihua University, Jilin, China;2. Department of Pathology, The General Hospital of CNPC in Jilin, Jilin, China;3. Department of Pharmacology, School of Basic Medical Sciences, Peking University, and State Key Laboratory of Natural and Biomimetic Drugs, Beijing, China;1. Department of Pathomorphology, Collegium Medicum, Jagiellonian University, ul. Grzegorzecka 16, 31-531 Kraków, Poland;2. Department of Urology, Collegium Medicum, Jagiellonian University, ul. Grzegorzecka 18, 31-531 Kraków, Poland;1. Laboratory of Veterinary Histopathology in Komarno, Slovak Republic;2. Department of Animal Husbandry, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences in Prague, Czech Republic;3. Physiology of Nutrition and Quality of Animal Product, Institute of Animal Science in Prague – Uhrineves, Czech Republic;4. Department of Biology, Pedagogical Faculty, Selye Janos University in Komarno, Slovak Republic;5. Institute of Experimental Medicine, Academy of Sciences of the Czech Republic in Prague, Czech Republic;6. Department of Immunology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania;7. Student of Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences in Prague, Czech Republic;8. Department of Biology, University of Presov in Presov, Slovak Republic;1. Associate Professor of Oral and Maxillofacial Surgery, Oral and Maxillofacial Diseases Research Center, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran;2. Assistant Professor of Oral and Maxillofacial Pathology, Dental Research Center, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran;3. Student of Oral and Maxillofacial Surgery, Oral and Maxillofacial Diseases Research Center, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran;1. Department of Pathology, Samsun Training and Research Hospital, Turkey;2. Department of Pathology, 19 Mayis University, Samsun, Turkey |
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| Abstract: | ![]()
The aim of the present study was to determine the chemokine RANTES (regulated on activation, normal T-cell expressed, and secreted) levels in plasma and atherosclerotic plaques and to assess their diagnostic efficacy in the evaluation of vulnerable plaques. The rabbit models of vulnerable atherosclerotic plaque (VAP) were established by high fat diet and pharmaceutical triggering. The serum RANTES levels of VAP group (91.97 ± 8.51 ng/ml) were significantly higher than those of AS (atherosclerosis) group (50.03 ± 2.92 ng/ml). Consistently, the mRNA and protein of RANTES in vulnerable atherosclerotic plaques were also obviously up-regulated compared to AS group (P < 0.01). Moreover, corrected plaque area and vulnerability index of VAP group proved to be significantly higher than AS group. The correlation coefficient between RANTES and plaque vulnerability indicated that RANTES, especially plaque RANTES, was positively correlated with VAP. In addition, increased expression of nuclear factor kappa B p65 (NF-κB p65) was observed in VAP group compared to AS group (P < 0.05), which partly accounted for the increased RANTES levels. In conclusion, positive associations between RANTES and plaque vulnerability suggest that higher RANTES levels may be associated with atherosclerosis and high-risk plaques. Our study highlights the utility of both serum and plaque RANTES levels as indicators of plaque vulnerability in the field of preventive cardiology. |
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| Keywords: | Atherosclerosis Vulnerable atherosclerotic plaque RANTES NF-κB p65 |
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