心律泰胶囊抗实验性心律失常的实验研究

目的：研究心律泰胶囊对实验性心律失常的作用。方法：用乌头碱、氯化钡、哇巴因、缺血再灌4种方法建立心律失常动物模型，观察心律泰的抗心律失常作用。结果：心律泰剂量依赖性地提高乌头碱致大鼠室早（VP）、室速（VT）、室颤（VF）、心脏停搏（CA）的阈剂量（P＜0．05）；剂量依赖性地缩短氯化钡引起的大鼠心律失常的持续时间（P＜0．01）；提高哇巴因致豚鼠VP、VT、VF、CA的阈剂量（P＜0．01）；缺血再灌模型中，大鼠VP出现时间及个数、VT持续时间、心律失常持续时间均显著性改善（P＜0．05）。在4种模型中，与宁心室、奎尼丁相比无显著性差异（P＞0．05）。结论：心律泰胶囊具有抗实验性心律失常作用，离子作用机制可能与阻Na^ 、Ca^2 内流，促K^ 外流有关。

Experimental Study on Antiarrhythmic Effects of Xinlu Tai Capsule

Objective To investigate the antiarrhythmic effects of Xinlu Tai Capsule (XTC). Methods Animal models with arrhythmia were induced by aconitine, barium chloride, ouabain and ischemia/reperfusion. Results XTC increased the threshold dose of aconitine in inducing ventricular premature beat (VPB), ventricular tachycardia (VT), ventricular fibrillation (VF) and cardiac arrest (CA) ( P < 0. 05) and shortened the persistent period of arrhythmia induced by barium chloride ( P < 0. 01) in rats in a dose - dependent manner. XTC could also increased the threshold dose of ouabin in inducing VPB, VT, VF and CA( P < 0. 01) and improve the attacking - time and the number of VPB, persistent period of VT and arrhythmia induced by ischemia/reperfusion( P < 0. 05). The differences in the above four groups did not differ from those in Ningxinbao and quinidine ( P > 0. 05). Conclusion XTC has an antiarrhythmic effect and its mechanism may be associated with inhibition of sodium and calcium ions influx and promotion of potassium ion outflux.