Body core temperature and depression during total sleep deprivation in depressives |
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| Authors: | S Elsenga R H Van den Hoofdakker |
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| Affiliation: | Department of Biological Psychiatry, University Psychiatric Clinic, Groningen, The Netherlands. |
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| Abstract: | Endogenously depressed patients were subjected to a total sleep deprivation (TSD) schedule of sleep-TSD-sleep-TSD. They were simultaneously treated with the antidepressant drug clomipramine. Self- and observer-rated depression was measured daily. Continuously measured rectal temperature (RT) data were available for the second TSD. It was found that a higher nocturnal minimum RT during this TSD was associated with a positive clinical response. |
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